Impact of physical factors on morphological features in patients with duodenal ulcer

Abstract

The study was conducted on 57 patients with intestinal dysbacteriosis. Among them, there were 22 women and 27 men. The age of the patients ranged from 18 to 65 years. All patients were diagnosed with dysbacteriosis. Verification of peptic ulcer disease was established endoscopically, the presence of Helicobacter pylori by enzyme immunoassays, dysbiosis of the large intestine by microbiological research methods. Patients were divided into 3 groups: 23 patients who received therapy with sinusoidal modulated waves, 19 patients who received therapy with transcranial electrical stimulation, and 15 patients who received therapy with sinusoidal modulated waves to the area of ​​the duodenal triangle and transcranial electrical stimulation. The control group consisted of patients (20 patients) who received standard eradication therapy according to the recommendations of the Maastricht V/Florence Consensus on the treatment of Helicobacter infection. The obtained data allow us to state that the inclusion of physical factors in the eradication therapy scheme leads to a more pronounced positive change in the cellular composition of the duodenal mucosa, which may indicate a decrease in the activity of inflammatory and immunoinflammatory processes. It has also been proven that therapy with sinusoidally modulated waves and transcranial electrical stimulation in combination significantly exceeds the similar direction of the effects of standard eradication therapy schemes in their morphological effectiveness. It can be assumed that more positive dynamics in relation to the elimination of Helicobacter pylori infection is associated with a decrease in the density of neutrophilic and plasmacytic infiltration at the edges of ulcerative defects of the duodenal bulb.